Morning and evening, after cleansing your skin with Gentle Cleanser by Pro-Derm, apply 5 drops on your face, neck and neckline. In the morning, layer with an SPF 30 sun protection. In the evening, apply the treatment recommended by your doctor. For enhanced brightening treatment: Overlay C 10% Vitamin Serum with M2PE and Antioxidant Serum. Always apply the C 10% Vitamin Serum first, followed by Antioxidant Serum.